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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FEN1
All Species:
28.18
Human Site:
Y268
Identified Species:
56.36
UniProt:
P39748
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P39748
NP_004102.1
380
42593
Y268
R
R
L
D
P
N
K
Y
P
V
P
E
N
W
L
Chimpanzee
Pan troglodytes
XP_001149490
346
39044
D248
I
G
P
K
R
A
V
D
L
I
Q
K
H
K
S
Rhesus Macaque
Macaca mulatta
XP_001118506
412
46252
D314
I
G
P
K
R
A
V
D
L
I
Q
K
H
K
S
Dog
Lupus familis
XP_533271
380
42605
Y268
R
R
L
D
P
N
K
Y
P
V
P
E
N
W
L
Cat
Felis silvestris
Mouse
Mus musculus
P39749
378
42296
Y266
R
R
L
D
P
S
K
Y
P
V
P
E
N
W
L
Rat
Rattus norvegicus
NP_445882
380
42603
Y268
R
R
L
D
P
S
K
Y
P
V
P
E
N
W
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001072959
381
42965
Y268
Q
H
I
D
T
K
K
Y
P
L
P
E
N
W
L
Frog
Xenopus laevis
P70040
382
42650
Y268
D
N
I
D
L
K
K
Y
P
V
P
E
N
W
L
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523765
385
42930
Y268
D
N
L
D
S
S
K
Y
T
V
P
E
N
W
N
Honey Bee
Apis mellifera
XP_395769
379
42891
F268
E
N
L
D
T
K
K
F
P
I
P
E
D
W
N
Nematode Worm
Caenorhab. elegans
NP_491168
382
42531
Y268
E
N
I
D
Q
N
K
Y
P
P
P
E
D
W
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P26793
382
43261
S266
E
F
I
E
S
G
E
S
N
N
T
K
W
K
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91
83.2
98.1
N.A.
95.5
95.7
N.A.
N.A.
84.2
79.8
N.A.
N.A.
62.5
62.3
61.2
N.A.
Protein Similarity:
100
91
83.9
99.2
N.A.
97.1
98.4
N.A.
N.A.
93.1
90.8
N.A.
N.A.
78.9
80.2
76.6
N.A.
P-Site Identity:
100
0
0
100
N.A.
93.3
93.3
N.A.
N.A.
60
66.6
N.A.
N.A.
60
46.6
53.3
N.A.
P-Site Similarity:
100
20
20
100
N.A.
100
100
N.A.
N.A.
80
73.3
N.A.
N.A.
66.6
66.6
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
56.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
72.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
17
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
17
0
0
75
0
0
0
17
0
0
0
0
17
0
0
% D
% Glu:
25
0
0
9
0
0
9
0
0
0
0
75
0
0
0
% E
% Phe:
0
9
0
0
0
0
0
9
0
0
0
0
0
0
0
% F
% Gly:
0
17
0
0
0
9
0
0
0
0
0
0
0
0
0
% G
% His:
0
9
0
0
0
0
0
0
0
0
0
0
17
0
0
% H
% Ile:
17
0
34
0
0
0
0
0
0
25
0
0
0
0
9
% I
% Lys:
0
0
0
17
0
25
75
0
0
0
0
25
0
25
0
% K
% Leu:
0
0
50
0
9
0
0
0
17
9
0
0
0
0
50
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
34
0
0
0
25
0
0
9
9
0
0
59
0
17
% N
% Pro:
0
0
17
0
34
0
0
0
67
9
75
0
0
0
9
% P
% Gln:
9
0
0
0
9
0
0
0
0
0
17
0
0
0
0
% Q
% Arg:
34
34
0
0
17
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
17
25
0
9
0
0
0
0
0
0
17
% S
% Thr:
0
0
0
0
17
0
0
0
9
0
9
0
0
0
0
% T
% Val:
0
0
0
0
0
0
17
0
0
50
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
9
75
0
% W
% Tyr:
0
0
0
0
0
0
0
67
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _